怀孕期间氧化应激生物标志物与7.5个月的婴儿认知之间的关联
Stephanie M Eick1, Kaegan Ortlund2, Andréa Aguiar3,4
1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Developmental psychobiology
|February 22, 2024
概括
怀孕期间的氧化压力可能会影响婴儿的认知发育. 某些氧化应激生物标志物的较高水平与减少新奇的偏好有关,这表明婴儿的识别记忆较差.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 环境健康 环境健康
背景情况:
- 氧化压力与神经发育迟缓有关.
- 对氧化应激和婴儿认知结果的研究是有限的.
- 婴儿期是大脑发育的关键时期.
研究的目的:
- 研究母亲尿路氧化应激生物标志物与婴儿认知功能之间的关联.
- 评估对信息处理速度,识别记忆和注意力的影响.
主要方法:
- 来自伊利诺伊州儿童发展研究的一个子集 (N=144) 的分析.
- 测量了四个尿路氧化应激生物标志物 (8-异质-PGF2α,2,3-丁-5,6-二-8-异-PGF2α,2,3-丁-8-异-PGF2α,前列腺素-F2α) 从第二和第三季度.
- 使用视觉识别记忆任务评估婴儿认知,测量新奇的偏好,运行时间,熟悉的时间和转移率.
主要成果:
- 高水平的8-异质-PGF2α,2,3-迪诺-8-异质-PGF2α和前列腺素-F2α与减少新奇的偏好有关.
- 这些生物标志物也与转工率的适度增加有关.
- 研究结果表明,母亲的氧化压力与婴儿的识别记忆之间存在潜在联系.
结论:
- 孕妇在怀孕期间接触氧化压力可能会对婴儿的认知发育产生负面影响,特别是识别记忆.
- 需要进一步的研究来证实这些关联并探索潜在的机制.
- 早期的氧化压力可能是影响神经发育轨迹的可修改因素.
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