[严重的小肠干扰和慢性肠道伪阻塞在全身性硬化症 (硬皮病):病理生理学,诊断和治疗基础,包括腹腔营养]
B Suzon1, F Louis-Sidney2, A Abel3
1Médecine Interne, CHU de Martinique, Fort-de-France, Martinique; Unité EpiCliV, Université des Antilles, Fort-de-France, Martinique.
概括
系统性硬化可以导致严重的胃肠道问题,如慢性肠道伪阻塞,导致营养不良. 腹腔营养是一种可行的长期支持选择,但需要专家监测以防止并发症.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 临床营养学 临床营养学
背景情况:
- 系统性硬化症经常涉及胃肠道,可能导致慢性肠道伪阻塞 (CIPO) 由于运动障碍.
- CIPO与抗纤维素/U3RNP抗体和细菌过度生长有关,需要抗生素治疗.
- 这种情况会导致严重的营养不良,由于恶心和吐等症状的食物摄入量减少.
研究的目的:
- 审查系统性硬化症中胃肠道参与的管理,重点是CIPO.
- 评估系统性硬化症患者体内营养的安全性和有效性.
- 讨论相关的治疗方法和潜在的并发症.
主要方法:
- 对系统性硬化症的胃肠道表现研究的文献综述.
- 对系统性硬化症患者的肠外营养数据的分析.
- 对CIPO和营养不良的治疗策略的评估.
主要成果:
- 亲肠道营养是一种安全有效的长期支持系统性硬化症患者的CIPO.
- 植入中央静脉导管不会增加感染或皮肤并发症的风险.
- 专家监测对于管理营养需求和预防心脏和肝胆道问题至关重要.
结论:
- 胃肠道干扰,特别是CIPO,是系统性硬化症的一个严重并发症.
- 腹腔营养是这些患者营养不良的可行和必要的干预措施.
- 营养专家参与的多学科管理对于最佳结果至关重要.
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