从1990年到2019年,多抗药结核病的全球流行率和负担
Hengliang Lv1,2, Xin Zhang1,2, Xueli Zhang3
1Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
BMC infectious diseases
|February 22, 2024
概括
耐多药结核病 (MDR-TB) 仍然是一个重大的全球健康威胁. 这项研究显示,从1990年到2019年,结核病发病率,流行率和死亡率都在上升,这凸显了迫切需要采取全球行动来减少结核病负担.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 构成了重大的全球卫生挑战,多药耐药结核病 (MDR-TB) 构成了关键威胁.
- 可靠的流行病学数据对于有效的公共卫生战略对抗MDR-TB至关重要.
研究的目的:
- 对MDR-TB的全球流行和负担进行全面的流行病学评估.
- 分析1990年至2019年的MDR-TB的趋势.
主要方法:
- 利用了来自2019年全球疾病负担 (GBD) 数据库的数据.
- 估计的年龄标准化流行,发病率,残疾调整寿命年 (DALYs) 和死亡率.
- 使用Joinpoint回归分析时间趋势,计算年平均百分比变化 (AAPC).
主要成果:
- 2019年,全球MDR-TB估计包括687,839例病例,非洲和东南亚的负担显著.
- 与女性相比,男性的MDR-TB流行率,DALY和死亡率较高,且随着年龄的增长而增加.
- 从1990年到2019年,在MDR-TB发病率 (AAPC=5.8%),流行率 (AAPC=5.9%),DALYs (AAPC=4.6%) 和死亡率 (AAPC=4.4%) 中观察到全球显著增加.
结论:
- 这项研究证实了耐药结核病对公众健康的持续和日益增长的威胁.
- 需要采取紧急,协调的全球行动,以实施有效的措施来减少MDR-TB负担.
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