M2巨细胞通过阻断脂肪细胞Ets1独立地促进色脂肪生成
Suyang Wu1, Chen Qiu1,2,3, Jiahao Ni1
1Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 211166, China.
Nature communications
|February 22, 2024
概括
脂肪组织巨细胞通过抑制脂肪细胞中的Ets1直接促进色脂肪的形成,独立于交感神经系统. 这一过程提高了线粒体的含量和能量消耗.
科学领域:
- 代谢和内分泌学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 脂肪组织巨细胞 (ATM) 影响色脂肪组织热生成,可能是通过同情活动.
- 人们对ATM调节色脂肪细胞形成的确切机制尚不完全了解.
研究的目的:
- 调查皮下ATM在促进色脂肪组织形成中的直接作用.
- 为了识别参与巨细胞-脂肪细胞通信中的分子媒介.
主要方法:
- 在小鼠的手术共感切除术.
- 皮下脂肪组织巨细胞的消耗.
- 对脂肪细胞中Ets1表达的分析.
- 评估线粒体生物发生和清除.
- 生成和分析脂肪细胞特异的Ets1敲进和敲除小鼠模型.
主要成果:
- 皮下ATM直接促进色脂肪细胞的形成,独立于交感内.
- 抗炎M2巨细胞抑制脂肪细胞Ets1的表达.
- 由M2巨细胞抑制Ets1增强了线粒体生物发生,并抑制了线粒体清除,增加了线粒体含量.
- 脂肪细胞中Ets1的损失导致冷不耐受,而其缺失则增加了能量消耗和代谢障碍的抵抗力.
结论:
- 在M2巨细胞和脂肪细胞之间存在直接的沟通通路,促进色脂肪细胞的形成.
- 脂肪细胞Ets1充当关键的调解者,响应巨细胞信号,调节线粒体含量和色脂肪细胞的发育.
更多相关视频
08:31Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
3.1K
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
2.1K
相关概念视频
Cell Specific Gene Expression
13.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.3K
Abnormal Proliferation
4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
