人类的肠道和全身食后乳酸穿阶段以及饮食碳水化合物碳流
Robert G Leija1, Casey C Curl1, Jose A Arevalo1
1Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, CA, USA.
Nature metabolism
|February 22, 2024
概括
饮食中的葡萄糖在肠道中转化为乳酸并运送到肝脏进行储存,挑战了以前关于碳水化合物代谢的信念. 这种食后乳酸穿 (PLS) 突出了乳酸.
科学领域:
- 人类生理学 人类生理学
- 代谢途径 代谢途径
- 碳水化合物的新陈代谢.
背景情况:
- 饮食中的葡萄糖主要以肝脏糖原的形式储存.
- 传统观点假设直接将葡萄糖转化为糖原.
- 餐后乳酸穿 (PLS) 假设提出了一个替代途径.
研究的目的:
- 研究人类中食后乳酸穿 (PLS) 的存在和作用.
- 为了确定乳酸是否是食葡萄糖代谢和储存中的中间体.
- 挑战乳酸生产仅与缺氧相关的假设.
主要方法:
- 在健康的年轻成年人中进行口服葡萄糖耐受性测试.
- 测量动脉化的乳酸和葡萄糖度.
- 血液中乳酸的出现率的确定.
主要成果:
- 乳酸水平在葡萄糖水平之前增加,表明肠道PLS.
- 一个与葡萄糖水平相关的二次,全身PLS阶段,由肝脏释放的葡萄糖驱动.
- 乳酸盐的产生发生在完全有氧的组织中,而不仅仅是缺氧的组织.
结论:
- 证据支持人类的食后乳酸穿 (PLS).
- 饮食中的碳水化合物是通过乳酸运输加工的.
- 乳酸糖是人类碳水化合物分布和新陈代谢的关键载体.
更多相关视频
14:42Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
Published on: September 23, 2021
4.8K
07:18Author Spotlight: Advances in Brain Energy Metabolism Research Using the Drosophila Model
Published on: October 27, 2023
719
相关概念视频
Metabolic States of the Body: The Absorptive State
687
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
687
Overview of Carbohydrate Metabolism
1.0K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.0K
Metabolic States of the Body: The Postabsorptive State
313
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
313
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Dietary Connections
50.4K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
50.4K
Carbohydrate Absorption
725
Carbohydrates are essential macronutrients that serve as the body's primary energy source. Their digestion begins in the mouth, where salivary amylase partially breaks down complex carbohydrates such as starch into smaller oligosaccharides. This mechanical and enzymatic activity prepares carbohydrates for further processing in the gastrointestinal tract.
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
725
