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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: Jul 2, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

使用深度大脑刺激,绘制前额叶皮层中的功能障碍电路.

Barbara Hollunder^1,2,3, Jill L Ostrem⁴, Ilkem Aysu Sahin^1,2

¹Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Nature neuroscience

|February 22, 2024

概括

此摘要是机器生成的。

深度大脑刺激 (DBS) 分析揭示了与运动,认知和情感障碍有关的明显的正面电路. 绘制这些功能障碍电路的地图为神经疾病中的大脑结构功能关系提供了新的见解.

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科学领域:

神经科学是一个神经科学.
神经学神经学
大脑连接学 (Connectomics)

背景情况:

额头回路对于运动,认知和情感功能至关重要.
这些电路的功能障碍与各种大脑疾病有关.
调解这些功能的特定额头领域在很大程度上仍未定义.

研究的目的:

为了研究在不同脑部疾病中变得功能障碍的特定前额回路.
通过深度大脑刺激来探索大脑结构,功能障碍和治疗调制之间的关系.

主要方法:

对534个植入四种不同脑部疾病的深度脑刺激 (DBS) 电极的分析.
最佳治疗反应与调节的大脑连接的相关性.
基于连接模式的功能障碍的前部电路的地形绘制.

主要成果:

对于每个研究的疾病,前额叶皮质分为不同的功能障碍电路.
特定电路拓的识别:感觉运动皮层 (静脉缩),初级运动皮层 (图雷特综合征),补充运动区域 (帕金森病) 和腹中前额/前带皮层 (强迫症).

结论:

与大脑连接学集成的深度大脑刺激是探索大脑结构-功能合的强大方法.
结果描述了与不同的神经和精神疾病相关的特定前额电路功能障碍.
这种方法提升了我们对大脑疾病神经基础的理解.