在脊髓损伤的人群中观察冷气诱导的血管扩张
Yasuhisa Fujita1, Yoshi-Ichiro Kamijo2,3, Tokio Kinoshita1
1Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan.
Spinal cord
|February 22, 2024
概括
脊髓损伤 (SCI) 患者在感觉和非感觉皮肤区域都表现出冷引起的血管扩张. 这种保护性反应对于预防伤至关重要,即使在感觉受损的区域也可以观察到.
科学领域:
- 身体生理学 身体生理学
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
背景情况:
- 感冒引起的血管扩张是健康个体对抗感冒损伤的关键保护机制.
- 脊髓损伤 (SCIs) 可以扰乱热调节通路,引发有关受影响个体对寒冷的血管反应的问题.
研究的目的:
- 调查不同程度脊髓损伤的个体中冷感应血管扩张的存在和特征.
- 为了确定皮肤血流对局部冷却的反应是否在SCI患者的感觉和非感觉区域之间有所不同.
主要方法:
- 一项急性实验性研究涉及部 (SCIC) 和胸脊 (SCITL) 脊髓损伤的参与者.
- 局部冷却应用于感觉 (胸部) 和非感觉 (大腿) 皮肤区域,逐渐降低温度至15°C和8°C.
- 在整个冷却方案中,使用激光多普勒流量计测量皮肤血流 (SkBF).
主要成果:
- 在局部降温期间,在SCI参与者的感觉和非感觉区域观察到SkBF的增加.
- 与非感觉大腿区域相比,感觉胸部区域的SkBF增加幅度更大.
- 虽然SkBF在非感觉大腿增加,但在测试的冷却条件下,它并没有始终超过基线水平.
结论:
- 局部冷却在脊髓损伤的个体中引起皮肤区域的血管扩张反应,有或没有感觉.
- 感觉性皮肤区域在暴露于寒冷的过程中,皮肤血流的增加比非感觉性皮肤区域更明显.
- 这些发现表明SCI个体的局部血管温度调节的残余能力,尽管可能由感官输入调节.
相关概念视频
01:16Spinal Cord: Cross-sectional Anatomy
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
01:26Spinal Cord
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
01:27Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
01:14Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...