相关实验视频

Updated: Jul 2, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

[在前列腺癌中转移导向治疗]

Angelika Borkowetz^1,2, Tobias Hölscher^3,4

¹Klinik und Poliklinik für Urologie, Universitätsklinikum Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. angelika.borkowetz@uniklinikum-dresden.de.

Urologie (Heidelberg, Germany)

|February 22, 2024

概括

以转移为导向的疗法 (MDT) 对寡头转移性前列腺癌 (omHSPC) 是有前途的,有可能延迟进展并改善预后. 需要进一步的研究来澄清其作用,特别是同步omHSPC.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
分子成像学分子成像学

背景情况:

以转移为导向的疗法 (MDT) 正在对寡头转移性前列腺癌 (omHSPC) 变得越来越重要.
前列腺特异性膜抗原正子发射断层扫描 (PSMA-PET) 提高了转移的早期检测.
早期发现有助于及时进行治疗干预.

研究的目的:

评估MDT在管理OMHSPC中的作用.
评估MDT对疾病进展和预后的影响.
探索PSMA-PET在识别MDT候选者的实用性.

主要方法:

对OMHSPC当前治疗策略的审查.
对MDT,包括放射治疗的潜在试验的分析.
考虑抗雄激素剥夺疗法 (ADT) 和新型荷尔蒙疗法 (NHT).

主要成果:

多种多种疗法,特别是放射疗法,已经显示出在甲时性omHSPC中延长无ADT间隔和无进展生存 (PFS) 的潜力.
额外的ADT可能会进一步改善PFS.
对于同步的omHSPC,存在有限的前性数据.

结论:

尽管证据有限,但MDT对OMHSPC的认可越来越大.
为了进行数据比较,需要对寡头转移和影响因素的标准化定义.
需要对MDT进行进一步的研究,特别是同步的omHSPC,以及其与ADT/NHT的组合.

关键词:

抗雄激素疗法是一种抗雄激素疗法.以转移为导向的疗法.基转移性前列腺癌的前列腺癌.进行激进的前列腺切除术.辐射疗法辐射疗法

更多相关视频

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...