甲基双F:另一个潜在的肥胖原体
Misha Singh1, Jennifer Crosthwait1, Alexander Sorisky2,3,4
1Environmental Health Science and Research Bureau (EHSRB), Health Canada, 251 Sir Frederick Banting Driveway, Ottawa, ON, K1A 0K9, Canada.
International journal of obesity (2005)
|February 22, 2024
概括
四甲基双F (TMBPF) 和双F (BPF) 促进脂肪细胞的发育,双F更强于双A (BPA). 这些BPA替代品可能会作为肥胖化学品带来风险.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 全球肥胖和代谢疾病的增加与生活方式和遗传学有关.
- 像双A (BPA) 这样的环境化学物质越来越多地与肥胖有关.
- 制造商正在用类似物代替BPA,需要进行毒理学评估.
研究的目的:
- 为了研究BPA类似物的脂肪生成潜力:四甲基双F (TMBPF),双F (BPF),双AP (BPAP) 和-9-双 (BHPF).
- 为了比较这些类似物与BPA对脂肪细胞分化的影响.
主要方法:
- 在分化过程中,用BPA及其类似物 (0.0120μM) 处理了小鼠3T3-L1细胞.
- 评估脂质积累和脂肪生成标记物 (mRNA和蛋白质) 的表达.
主要成果:
- 在120μM时,TMBPF,BPF和BPA显著增加了脂质积累和脂肪基因表达 (Lpl,Fabp4,Plin).
- TMBPF表现出比BPA和其他类似物更强大的脂肪生成效应.
- TMBPF对Fabp4表达的影响表明过氧体增殖器激活受体 (PPAR) 的γ激活.
结论:
- BPF模仿BPA的效果,而TMBPF是最强大的脂肪生成类似物.
- TMBPF作为PPARγ激动剂,表明它是一个肥胖的化学物质和潜在的代谢破坏者.
更多相关视频
00:05In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
Published on: August 28, 2019
13.9K
09:04Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
Published on: April 18, 2019
12.4K
相关概念视频
01:24Obesity
501
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
501
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K