使用DART-TD-HRMS快速选骚乱控制剂
Lina Mörén1, Anders Östin1, Andreas Larsson1
1FOI, Swedish Defence Research Agency, CBRN Defence & Security, SE 901 82, Umeå, Sweden.
Forensic toxicology
|February 22, 2024
概括
这项研究提出了一种快速方法,用于检测16个暴乱防治剂 (RCAs) 在服装表面使用实时直接分析与高分辨率质谱 (DART-HRMS). 该技术可以快速选潜在的RCA滥用.
科学领域:
- 法医化学 法医化学
- 分析化学 分析化学
- 化学武器分析 化学武器分析
背景情况:
- 防暴剂 (RCAs) 是用于执法和冲突的化学物质,有16种潜在的代理物被禁止化学武器组织科学咨询委员会确定.
- 滥用RCAs用于犯罪目的需要开发有效的检测方法.
- 目前的检测方法可能不适合对服装等表面进行快速,高通量选.
研究的目的:
- 评估一种快速,高通量选方法的可行性,用于检测表面,特别是服装上的RCAs.
- 评估实时直接分析的实用性,再加上热溶解装置和高分辨率质谱 (DART-TD-HRMS) 用于RCA检测.
主要方法:
- 开发和测试一种广泛适用的方法来检测潜在的RCAs.
- 用自卫喷雾剂处理的棉织物样本的分析.
- 使用DART源进行直接表面擦拭样本分析的调查.
主要成果:
- 开发的方法成功检测出所有16个已识别的RCAs.
- 污染的服装样本被有效地选出自卫喷雾剂的参考集合中的活性剂.
- 一项试点研究表明,RCAs可以通过直接向DART源呈现样本来检测.
结论:
- 实时直接分析与热溶解和高分辨率质谱 (DART-TD-HRMS) 提供了一个快速而简单的选解决方案,用于织物上的RCAs.
- 这种方法促进了在表面上检测RCA的高样本吞吐量.
- DART-TD-HRMS技术是一个有前途的工具,用于识别潜在的RCA滥用.
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