相关实验视频

Updated: Jul 2, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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通过加强KSR-MEK相互作用,CNK-HYP脚手架综合体促进了RAF的激活

Pierre Maisonneuve1,2, Malha Sahmi3, Fanny Bergeron-Labrecque3

  • 1Université de Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, F-33600, Pessac, France. p.maisonneuve@iecb.u-bordeaux.fr.

Nature structural & molecular biology
|February 22, 2024
PubMed
概括

脚手架蛋白 CNK 和 HYP 稳定了 RAS-MAPK 路径内的相互作用,增强了 RAF 激活. 这种稳定对于细胞信号传递和癌症发展至关重要,揭示了新的调节机制.

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Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells06:44

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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