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加拿大大麻对甲基诱导的肺损伤的影响

Ozlem Ozmen¹, Adem Milletsever¹, Serife Tasan¹

¹Faculty of Veterinary Medicine, Department of Pathology, Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

Basic & clinical pharmacology & toxicology

|February 22, 2024

概括

大麻二醇 (CBD) 可能会防止癌症药物甲索 (MTX) 引起的肺损伤. CBD治疗逆转了老鼠肺部的有害变化,显示了缓解甲基诱导的肺损伤的治疗前景.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
肺部病理学肺部病理学

背景情况:

甲托雷克萨特 (MTX) 是一种重要的化疗剂,已知具有肺毒性.
大麻二醇 (CBD) 具有抗氧化和抗炎性质,表明其可能具有器官保护作用.
由MTX引起的肺损伤是一个重要的临床问题,需要有效的治疗策略.

研究的目的:

在大鼠模型中调查大麻素 (CBD) 对甲基 (MTX) 诱导的肺损伤的潜在保护作用.
评估CBD对MTX诱导的肺损伤的组织病理和分子标记物的影响.

主要方法:

雌性Wistar Albino大鼠被分配到四个组:对照组,MTX,MTX + CBD和仅CBD.
使用组织病理学,免疫组织化学 (对于Cas-3,TNF-α,NF-κB) 和PCR (对于Apaf 1,GRP 78,CHOP,Cyt C,BCL 2) 分析了肺组织.
MTX是作为单次腹膜内注射剂的,而CBD是每天给予七天.

主要成果:

暴露于MTX导致显著的肺病变,包括高血压,,炎症和上皮细胞损失.
MTX增加了Cas-3,TNF-α和NF-κB的表达,同时增加了细胞亡标志物 (Apaf 1,GRP 78,CHOP,Cyt C) 的水平,并降低了BCL 2.
CBD治疗有效地逆转了MTX诱导的组织病理损伤,并使关键分子标记物的表达正常化.

结论:

大麻二醇 (CBD) 在大鼠中显示出显著的保护作用,防止甲索 (MTX) 诱导的肺损伤.
CBD通过减少炎症,亡和氧化应激减轻MTX诱导的肺损伤.
这些发现表明,CBD是预防或治疗MTX相关肺毒性的潜在治疗剂.

关键词:

在Cannabidiol中使用.免疫组织化学免疫组织化学肺肺肺肺肺肺肺肺肺病理学的病理学

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