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选择体的现型一致分布在失语者和行为性痴呆症之间

Allegra Kawles^1,2, Rachel Keszycki^1,2, Grace Minogue^1,2

¹Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Acta neuropathologica communications

|February 23, 2024

概括

皮克病 (PiD) 病理分布与前叶退化亚型的临床症状相关. 新皮层Pick体分布与初级渐进性失言症和行为变体FTD保持一致,但海马参与在两者中都是显著的.

科学领域:

神经科学是一个神经科学.
神经病理学神经病理学
遗传学遗传学是一个

背景情况:

皮克病 (Pick's disease,PiD) 是一种特征为3R-tau入的病.
皮德是痴呆症综合征的基础,如初级渐进性失语症 (PPA) 和行为变异前性痴呆症 (bvFTD).
了解PiD的病理分布对于将其与临床表现相关联至关重要.

研究的目的:

为了调查新皮层和海马的皮克体分布在bvFTD和PPA.
建立PiD和不同的临床表型之间的临床病理学一致性.
探索陶病负担与特定痴呆症综合征之间的关系.

主要方法:

从大脑银行研究了18例PiD病例 (9个bvFTD,9个PPA).
使用AT8免疫组织化学可视化Pick体.
在多个大脑区域进行了无偏见的立体分析,包括新皮质和海马.

主要成果:

峰值新皮层Pick体密度不同:bvFTD中的中额头,PPA中的前叶.
PPA在下叶和上回形中显示出较大的左向病理.
bvFTD在上旋环中表现出右非对称的病理.
海马病理是显著的,并不是临床病理学上与新皮质发现一致.
在PPA中,dentate gyrus神经元受到不成比例的影响.

结论:

新皮层Pick体的分布与区分PPA和bvFTD的临床特征一致.
海马对3R-陶病的脆弱性需要进一步调查.
在PiD亚型中的临床病理相关性提供了对痴呆病变的洞察.

关键词:

行为变体前性痴呆症时间前性痴呆症前側葉退化前側葉退化皮克斯病就是皮克斯病.主要的渐进性失语症.立体学是一种立体学.塔乌·塔乌 (Tau Tau) 是一个

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