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自身免疫异常对小鼠生育能力和胎盘形态的影响

Risa Yamanaka¹, Osamu Ichii^1,2,3, Teppei Nakamura^2,4

¹Laboratory of Anatomy, Department of Basic Veterinary Sciences, Hokkaido University, Sapporo, Japan.

|February 23, 2024

概括

自身免疫性疾病 (AID) 影响小鼠的胎盘免疫力和生育能力. 虽然维持了生育能力,但易患艾滋病的小鼠表现出胎盘发育和基因表达的改变,突出显示了妊娠风险.

科学领域:

生殖免疫学生殖免疫学
母胎界面免疫学母胎界面免疫学
自身免疫性疾病的研究.

背景情况:

自身免疫性疾病 (AIDs) 可以通过改变胎盘免疫环境来破坏妊娠的结果.
了解这些变化对于管理艾滋病妇女的妊娠风险至关重要.

研究的目的:

与野生类型对照相比,研究AIDs对AID易患MRL/MpJ-Fas小鼠对怀孕和胎盘发育的影响.
在艾滋病严重程度的背景下分析生育状态,胎盘形态和综合基因表达.

主要方法:

MRL/MpJ-Fas和MRL/MpJ小鼠的交配 (定义为moLpr和moMpJ),并在妊娠日进行评估15.5.
评估AID指数 (脏重量,自身抗体),生育参数 (胎儿数量/大小) 和胎盘基因表达.
分析T细胞透,T辅助细胞功能相关基因和胎盘中的化学激素表达.

主要成果:

两种小鼠菌株均表现出相当的生育能力,但moLpr小鼠的胎盘和胎儿较轻,这表明生育能力降低,艾滋病严重程度增加.
在moLpr胎盘中,T细胞透率增加,与T辅助器2和T卵泡辅助器功能相关的基因表达率升高.
在moLpr胎盘中观察到妊娠/免疫调节基因 (Krt15,Slc7a3,Sprr2a3) 的显著改变和T细胞迁移化学因子 (Ccl5,Cxcl9) 的增加表达.

结论:

自身免疫性疾病显著改变胎盘形态功能,并影响小鼠的生育能力.
尽管观察到变化,但在检查的妊娠时间点保持生育能力.
这项研究提供了关于胎盘变化和与艾滋病相关的妊娠风险的见解.

关键词:

鼠标的MRL/MpJ-Faslpr/lpr是没有的.一个T细胞细胞.自身免疫性疾病是一种自身免疫性疾病.胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕

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