孤独作为神经行为问题在肌缩侧面硬化症中
Monica Consonni1, Veronica Faltracco1, Eleonora Dalla Bella1
13rd Neurology Unit and Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Luigi Celoria 11, Milan, 20133, Italy.
Annals of clinical and translational neurology
|February 23, 2024
概括
肌缩侧面硬化症 (ALS) 患者的孤独与行为变化和情绪失调有关,而不是运动或认知能力下降. 社会支持可能会增强对ALS神经行为变化的弹性.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 精神病学是一个精神病学.
背景情况:
- 孤独是一种已知的痴呆风险因素,对老年人的精神和身体健康产生影响.
- 孤独对肌缩侧面硬化症 (ALS) 的认知和行为功能的具体影响尚不清楚.
- 这项研究调查了孤独,运动功能,认知衰退和ALS患者的大脑结构之间的关系.
研究的目的:
- 确定孤独与ALS患者的运动,认知和行为功能之间的关系.
- 探索孤独对ALS皮质干预的潜在影响.
- 确定与ALS孤独相关的临床,遗传和神经心理特征.
主要方法:
- 200名ALS患者和50名健康对照人被评估了孤独感,情绪和生活质量.
- 患有ALS的患者接受了全面的临床,遗传和神经心理评估.
- 3T MRI扫描用于测量ALS患者的一个子集的皮质厚度.
主要成果:
- 在38%的ALS患者中,孤独存在,并与焦虑,抑郁和生活质量下降有关.
- 经历孤独的ALS患者表现出明显的行为特征和前对对面皮质干涉.
- 在ALS中孤独与行为变化,冷漠和情绪失调相关.
结论:
- 在ALS中,孤独与神经行为变化有关,并影响大脑结构,超出了运动状态.
- 患有ALS的患者的社会福祉与整体生活满意度有关.
- 促进社交行为可能会增强个人对ALS行为和情感衰退的弹性.
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