在接受头辐射治疗的患者中,眼睛表面的变化
H Sujithra1, Kannisha N Shah1, R Anoop2
1Department of Ophthalmology, Amrita Institute of Medical Sciences Kochi, Kerala, India.
Indian journal of ophthalmology
|February 23, 2024
概括
头癌的放射治疗导致干眼综合征. 对接受HNC辐射的患者来说,早期检测眼睛表面变化,包括梅博米腺功能障碍,至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 头癌辐射疗法 (HNC RT) 经常导致干眼综合征 (DES).
- 眼睛表面的损伤会影响结膜表皮,杯细胞,角膜,眼腺和梅博米腺.
- 早期检测眼睛表面变化对于管理HNC后的DES RT至关重要.
研究的目的:
- 评估和检测患者接受RT外眼HNC.早期的眼睛表面参数变化.
- 评估HNC RT对梅博米腺功能和膜稳定性的影响.
- 为了比较照射和非照射眼睛之间的眼睛表面变化.
主要方法:
- 评估了21名HNC RT患者的42只眼睛.
- 记录了辐射技术和眼睛剂量.
- 在RT前,RT后立即和RT后6周评估梅博米腺变化 (meiboscore),OSDI,希尔默测试,TBUT和裂灯检查.
主要成果:
- 催膜分解时间 (TBUT) 显著减少,RT后梅博斯core增加 (P < 0.001).
- 23.80%的患者显示OSDI得分>13后RT (P<0.001).
- 在ipsilateral和contralateral眼之间观察到TBUT和meiboscore的显著差异.
结论:
- 接受HNC RT的患者需要对眼表面和梅博米腺的变化进行随访.
- 反侧 (非辐射) 眼睛也需要评估.
- 接受较低眼部辐射剂量的患者也应受到监测.
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