关于预防性全胃切除术在生殖系CDH1变体携带者身上需要考虑的要点
Giovanni Corso1,2,3, Jeremy L Davis4, Vivian E Strong5
1Division of Breast Surgery, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Journal of surgical oncology
|February 23, 2024
概括
生殖系CDH1突变显著增加了扩散性胃和叶状乳腺癌的风险. 预防性全胃切除术为高风险的CDH1携带者提供了一种拯救生命的选择,尽管手术指示仍在争论中.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 手术瘤学手术瘤学
背景情况:
- 致病性生殖系CDH1突变与扩散性胃癌 (男性高达70%,女性高达56%) 和叶状乳腺癌的高终身风险有关.
- 无症状携带CDH1突变的人面临着相当大的癌症倾向.
- 早期的扩散性胃癌在这些个体的内镜监测中经常错过.
研究的目的:
- 审查在无症状生殖系CDH1突变携带者中预防性全胃切除术的支持和反对证据.
- 在胃癌风险较高的个体中,为有关手术干预的决策提供信息.
主要方法:
- 关于CDH1突变和预防性手术的研究和临床指南的文献综述.
- 在这个人群中对全胃切除术的风险因素,益处和禁忌的分析.
主要成果:
- 预防性全胃切除术是一种独特的方法,由于内镜查的局限性,对CDH1携带者来说可能是拯救生命的方法.
- 进行外科手术的决定是复杂的,需要考虑潜在的禁忌和患者特定因素.
结论:
- 生殖系CDH1突变携带者有胃癌和乳腺癌的高风险,需要仔细评估风险.
- 虽然预防性胃切除术是一种可行的选择,但其适用性需要在临床争议的背景下对益处和风险进行平衡的考虑.
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145
Peptic Ulcer Disease V: Surgical Management and Nursing Care
303
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
303
Barrett Esophagus-I: Introduction
98
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
98


