在抗VEGF静脉内注射后,眼替代物的临床评价效用
Cagini Carlo1, Maria Poddi1, Stefano Mocini1
1Department of Medicine and Surgery, Ophthalmology Section, University of Perugia, Perugia, Italy.
European journal of ophthalmology
|February 23, 2024
概括
这项研究发现,含有聚乙烯糖醇400,乙烯糖醇,基和氨酸的人造眼可以有效地减少因年龄相关的黄斑变性而进行内注射后干眼症状.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 干眼综合症 干眼综合症
背景情况:
- 常用于与年龄相关的黄斑退行症的肠内注射,可以诱导或加剧干眼症状.
- 注射后的眼部不适是接受抗VEGF治疗的患者经常抱怨的情况.
研究的目的:
- 为了评估一种特定的人工眼配方在缓解眼睛干燥后注射后干燥眼睛症状方面的有效性.
- 评估聚乙烯糖醇400 - 乙烯糖醇 - 基 - 氨酸眼滴对患者报告的结果的影响.
主要方法:
- 一个随机的平行组研究,涉及80名50岁以上的患有排泄性与年龄相关的黄斑变性.
- 患者接受了标准治疗或研究眼滴加标准治疗,在基线,15天和30天进行评估.
- 关键的评估包括眼破裂时间 (T-BUT),希尔默测试,光素染色以及DEQ5和OSDI问卷.
主要成果:
- 使用人工眼的研究小组显示DEQ5得分显著下降,表明干眼症状有所改善.
- 虽然像T-BUT和希尔默测试这样的客观测量没有显著变化,但OSDI问卷显示了研究组的统计学上显著的改善.
- 对照组在DEQ5或OSDI得分上没有显著改善.
结论:
- 含有聚乙烯糖醇400,乙烯糖醇,基和氨酸的人造眼在接受首次视窗内治疗的患者中有效降低术后眼部不适.
- 这种特殊的眼替代品可以显著改善患者在术后期报告的干眼症状.
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