癌症前史对脑瘤存活率的影响:一个倾向性得分调整的基于人口的研究
Mohammad Ebad Ur Rehman1, Fatima Faraz1, Huzaifa Ahmad Cheema2
1Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Cancer reports (Hoboken, N.J.)
|February 23, 2024
概括
以前的癌症史 (PCH) 通常不会影响脑癌存活率. 然而,特定的先前癌症 (胃肠道,血液/淋巴) 和质母细胞瘤可能会影响整体生存结果.
科学领域:
- 在瘤学瘤学.
- 临床流行病学临床流行病学
背景情况:
- 以前的癌症史 (PCH) 往往导致被排除在临床试验之外.
- 有证据表明,PCH不会对癌症患者的治疗结果产生不利影响.
- PCH对脑癌患者的生存影响在很大程度上是未知的.
研究的目的:
- 为了确定PCH在脑癌患者中的患病率.
- 评估PCH对整体存活率 (OS) 和脑癌特定存活率 (BCSS) 的影响.
主要方法:
- 使用SEER数据库 (2000-2019) 进行的回顾性队列研究.
- 包括脑癌患者作为第一个或第二个原发性恶性瘤.
- 使用了倾向分数匹配 (PSM) 和生存分析 (卡普兰-梅尔,考克斯模型).
主要成果:
- 在42,726名脑癌患者中,有2.78%患有PCH.
- PCH是OS (AHR1.26,p<.001) 的一个显著的风险因素,但不是BCSS (AHR0.97,p=.54).
- 以前的胃肠道和血液/淋巴恶性瘤显著影响了OS.
结论:
- PCH通常不会显著影响脑癌患者的生存率.
- 例外包括先前的胃肠道或血液/淋巴恶性瘤.
- 质母细胞瘤组织学也会影响生存结果.
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