[在口腔状细胞癌中癌症干细胞. 文献综述] 文献综述] 文献综述]
Mariana Paulina Rodríguez-Vargas1, Hugo Alvarado-Garnica2, Luis David Gutiérrez-Verdín3
1Laboratorio de Investigación Interdisciplinaria (LII), Área de Patología Oral y Maxilofacial. Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México. León, Guanajuato, México. rodriguezvargasp@gmail.com, fgvillanuevas@enes.unam.mx Universidad Nacional Autónoma de México Laboratorio de Investigación Interdisciplinaria (LII), Área de Patología Oral y Maxilofacial Escuela Nacional de Estudios Superiores (ENES) Unidad León Universidad Nacional Autónoma de México LeónGuanajuato Mexico rodriguezvargasp@gmail.com fgvillanuevas@enes.unam.mx.
口腔状细胞癌中的癌症干细胞驱动疾病的进展和治疗失败. 识别和准这些细胞为口腔癌提供了新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 干细胞研究 干细胞研究
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 癌症干细胞 (CSCs) 越来越被认为是瘤进展和各种癌症治疗耐药性的关键驱动因素.
- 了解CSC在OSCC中的作用对于开发有效的治疗策略至关重要.
研究的目的:
- 进行关于口腔状细胞癌 (OSCC) 癌症干细胞 (CSC) 的文献审查.
- 调查CSC与OSCC疾病进展,复发和转移的关联.
- 探索在OSCC中针对CSC的治疗影响.
主要方法:
- 在PubMed数据库中对2012年至2022年间发表的文章进行了系统的文献搜索.
- 搜索术语包括"新形成性干细胞"",癌症干细胞"",头部和部状细胞癌"和"口腔状细胞癌".
- 文章选择遵循PRISMA指南,最终评估了35篇相关文章.
主要成果:
- 口腔状细胞癌表现出细胞异质性,包括癌症干细胞的存在.
- 在OSCC中癌症干细胞与疾病进展,复发,转移和治疗失败有关.
- 干细胞标记物的表达有助于在OSCC中识别CSC,使它们与癌细胞行为有关.
结论:
- 癌症干细胞在口腔状细胞癌的发病和临床行为中起着至关重要的作用.
- 识别和描述CSC对于理解OSCC至关重要.
- 针对CSC的新型治疗方法正在开发中,以改善OSCC患者的治疗结果.
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