在累积剂量乙醇挑战中,一个多元组合乙醇响应电池显示,青少年老鼠对乙醇的响应性相对于成年人来说有所降低
Ryan P Vetreno1,2, Jeffrey Campbell1, Fulton T Crews1,2,3
1Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Advances in drug and alcohol research
|February 23, 2024
概括
与成年人相比,青少年大鼠的酒精反应较低,以减少中毒和低温为证. 这种敏感性下降可能会增加饮酒狂欢和酒精使用障碍 (AUD) 的风险.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 青春期是一个关键的发育时期,其特点是酒精反应减少.
- 在青少年时期这种较低的敏感性可能会使个人倾向于重度饮酒和酒精使用障碍 (AUD).
研究的目的:
- 为了研究和比较青少年和成年大鼠之间的乙醇 (酒精) 反应.
- 为了测试青少年大鼠表现出比成年大鼠更低的乙醇反应率的假设.
主要方法:
- 开发了一种乙醇反应电池 (ERB) 来评估累积剂量的急性乙醇影响.
- 评估了行为中毒,体温,血液中乙醇度 (BEC),运动协调 (旋转杆,倾斜平面) 和正反射 (LORR) 的损失.
- 在青少年 (产后40天) 和成年 (产后85天) 阶段使用雄性和雌性Wistar大鼠.
主要成果:
- 与成年人相比,青少年大鼠的中毒评级较低,低温反应减弱.
- 青少年在旋转杆上跌倒的延迟时间较长,在倾斜平面测试中损伤较少.
- 成年大鼠在3.0g/kg乙醇下始终失去了直立反射,而大多数青少年没有.
结论:
- 与成年人相比,青少年大鼠在多种生理和行为指标上表现出显著下降的乙醇反应能力.
- 这种青少年特有的低乙醇敏感性是导致青少年饮酒过度增加的潜在因素.
- 在青春期减少反应能力可能会增加以后生活中发展酒精使用障碍的风险.
更多相关视频
07:50A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
9.7K
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
579
相关概念视频
01:21Factors Affecting Drug Response: Overview
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...