产前大麻素暴露对早期发育及以后的影响
Megan K Mulligan1, Kristin M Hamre2
1Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center (UTHSC), Memphis, TN, United States.
Advances in drug and alcohol research
|February 23, 2024
概括
公众对怀孕期间使用大麻的看法往往与医疗建议相矛盾. 本综述检查了人类和动物研究中产前大麻素暴露 (PCE) 的潜在风险,突出了知识差距.
科学领域:
- 产科和妇科 产科和妇科
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 公众对怀孕期间大麻安全性的看法与倡导戒断的医疗指南形成鲜明对比.
- 合法化和社会接受有助于人们相信大麻对孕妇来说是安全的,有时用于治疗早晨恶心.
- 缺乏明确的医疗和联邦指南安全大麻使用水平加剧了这个问题.
研究的目的:
- 审查目前关于产前大麻素暴露 (PCE) 的潜在风险的研究.
- 探索关于怀孕期间使用大麻的公众态度和医疗建议之间的差异.
- 确定了解PCE对后代的影响的关键知识差距.
主要方法:
- 人类相关研究和临床前动物模型的审查,检查产前大麻暴露.
- 分析现有人体研究的局限性,包括道德限制,缺乏量化暴露数据,小样本大小和混因素.
- 临床前研究设计的评估,异质性和可翻译性对人类结果的挑战.
主要成果:
- 人类研究主要是相关的,防止子宫内大麻暴露与晚年生活结果之间的因果关系.
- 临床前研究表明可能存在因果关系,但异质性和物种差异限制了人类的直接应用.
- 在了解PCE的剂量反应关系和长期影响方面存在重大差距.
结论:
- 关于怀孕期间使用大麻的公众看法和医疗建议之间存在重大分歧.
- 目前的研究局限性阻碍了关于产前大麻素暴露的安全性或风险的最终结论.
- 需要进一步的研究来制定明确的指导方针,并解决围绕在怀孕期间使用大麻的公共卫生问题.
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