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在婴儿和幼儿中对胎儿酒精谱系障碍的查

Lauren Fleming¹, Connor Sheridan¹, Douglas Waite²

¹School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United States.

Advances in drug and alcohol research

|February 23, 2024

概括

胎儿酒精谱系障碍 (FASD) 是一种常见的神经发育障碍. 早期胎儿酒精频谱障碍查测试 (E-FAST) 有效地识别了患有FASD风险增加的幼儿,有助于早期干预.

科学领域:

神经发育障碍神经发育障碍
儿科健康儿科健康
公共卫生公共卫生

背景情况:

胎儿酒精谱系障碍 (FASD) 是最常见的神经发育障碍,影响多达5%的人口.
早期识别和干预对于改善FASD儿童发育结果至关重要.
胆补充剂有望改善产前酒精暴露导致的发育障碍.

研究的目的:

描述早期胎儿酒精频谱障碍查测试 (E-FAST) 的开发和验证.
使用具有可接受流行病学性能的查工具,识别患有FASD风险增加的幼儿.
为FASD提供早期识别和干预的临床工具.

主要方法:

开发了281名5岁以下儿童的E-FAST数据集 (180名患有FASD,101名没有).
确定了七个关键变量:产前酒精暴露,ADHD,寄养/收养,小头前围 (OFC),沟通障碍,社交技能缺陷和认知缺陷.
估计的风险比率和变量权重使用双向表分析对是/否分类变量.

主要成果:

单单母亲饮酒就显示出高灵敏度 (0.97) 和准确度 (0.86).
七项E-FAST屏幕实现了0.94的灵敏度,0.74的特异性和0.87.87的准确性.
E-FAST 工具表现出可接受的流行病学查特征,用于识别面临FASD风险的儿童.

结论:

在常规临床管理过程中,E-FAST查工具提供了一种时间效率高的方法来识别患有FASD风险增加的儿童.
来自E-FAST的积极查可以指导进一步的密集评估和对疑似患有FASD的儿童的随访.
电子快速工具可以帮助管理高发 FASD,这超过了诊断诊所的能力.

关键词:

胎儿酒精谱系障碍胎儿酒精谱系障碍婴儿时期的婴儿期神经发育障碍是一种神经发育障碍.在产前暴露于酒精的暴露.查检查查检查查检查查检查

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