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Updated: Jul 19, 2026

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全球代谢学揭示了结直肠癌患者的代谢衰老时钟的偏差

Long Zhang1,2,3, Shaobo Mo1,2, Xiurui Zhu4

  • 1Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Shanghai, China.

Theranostics
|February 23, 2024
PubMed
概括

这项研究开发了一个代谢衰老时钟,使用9个关键代谢物来评估生物年龄. 这种创新的血液测试在检测结肠直肠癌 (CRC) 和晚期癌前病变 (APL) 中表现有前途.

关键词:
衰老的衰老 衰老的衰老结肠直肠先进的癌前病变.结肠直肠癌是一种癌症.全球代谢学全球代谢学代谢衰老时钟 代谢衰老时钟

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...