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Updated: Jul 2, 2025

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从纳米纤维复杂薄膜中制备一种快速分解的药物输送系统

Asli Celebioglu1, Kareena Dash2, Mahmoud Aboelkheir1

  • 1Fiber Science Program, Department of Human Centered Design, College of Human Ecology, Cornell University Ithaca NY 14853 USA tu46@cornell.edu.

RSC medicinal chemistry
|February 23, 2024
PubMed
概括

纳普洛克森 (Naproxen) 是一种药物.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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