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小分子 WDR5 抑制剂降低 lncRNA 表达的调节

Jen-Yao Chang1, Cora Neugebauer1, Anne Mues Genannt Koers1

  • 1Chemical Genomics Centre of the Max Planck Society, Max Planck Institute of Molecular Physiology Otto-Hahn-Strasse 11 44227 Dortmund Germany peter.t-hart@mpi-dortmund.mpg.de.

RSC medicinal chemistry
|February 23, 2024
PubMed
概括

WD重复域5 (WDR5) 对于表观遗传基因调节至关重要. 用抑制剂准WDR5的WBM部位可以降低瘤性lncRNAs的调节,从而提供了一个新的治疗策略.

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