稳定性研究和验证的红外光谱测量方法的发展,用于定量分析sevoflurane与气色谱方法相比
1Department of Pharmaceutical, College of Pharmacy, Al-Farahidi University, Baghdad, Iraq.
Journal of advanced pharmaceutical technology & research
|February 23, 2024
概括
减弱的总反射率 - 里埃变换红外光谱 (ATR-FTIR) 提供了一种快速,准确的方法来量化sevoflurane,一个吸入麻醉剂. 虽然对于制药分析有效,但气相色谱对于检测杂质至关重要.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 频谱学是一种光谱学.
背景情况:
- 塞沃弗兰是通用麻醉的关键吸入麻醉剂.
- 传统的分析方法,如质谱和气相色谱,往往是繁的,需要复杂的设备.
- 需要有效且易于使用的分析技术来控制sevoflurane的质量.
研究的目的:
- 引入和验证一个减弱的总反射率-福里埃变换红外光谱法 (ATR-FTIR) 测量方法用于测定sevoflurane.
- 为了比较ATR-FTIR的疗效与现有的赛沃弗兰分析方法.
- 评估ATR-FTIR适用于药物质量控制sevoflurane的适用性.
主要方法:
- 使用ATR-FTIR光谱测量来定量测定塞沃.
- 在ATR-FTIR晶体上直接涂抹液体赛沃兰 (缩或稀释在六中).
- 验证方法的精度,准确性,可复制性和特异性.
主要成果:
- ATR-FTIR提供了一种快速,准确和易于使用的技术来定量sevoflurane.
- 作为稀释剂的素没有干扰光谱分析,特别是在1200厘米-1 (乙烯基组).
- 该ATR-FTIR方法已被验证用于识别和定量测定sevoflurane作为制药产品.
结论:
- ATR-FTIR光谱法是适合和有效的方法,用于定量分析和鉴定sevoflurane.
- 在sevoflurane稳定性研究中,气相色谱仍然是检测杂质和降解产品的必要条件.
相关概念视频
Gas Chromatography–Mass Spectrometry (GC–MS)
4.2K
Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a single instrument for analyzing a mixture of compounds. The gas chromatograph separates the compounds in the mixture, and the mass spectrometer analyzes each compound separately to determine the molecular masses and molecular structures.
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall....
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall....
4.2K
Gas Chromatography: Introduction
1.9K
Gas chromatography (GC) is a technique for separating and analyzing volatile compounds in a sample. Its primary purpose is to identify and quantify components in complex mixtures, making it essential in fields such as environmental analysis, pharmaceuticals, and petrochemicals. GC is also called vapor-phase chromatography (VPC) or gas-liquid partition chromatography (GLPC).
In GC, a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a...
In GC, a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a...
1.9K
Volatilization
386
Volatilization gravimetry is an analytical technique that measures the mass lost due to the volatilization of the substance. This technique is used to estimate the amount of volatile material in a sample. To perform this method, heat a known amount of the sample to a high temperature in a crucible or other suitable vessel. The volatile substance in the sample evaporates, and the vapor is completely expelled from the crucible either by heating the sample or bubbling a stream of inert gas through...
386
Supercritical Fluid Chromatography
248
Supercritical fluid chromatography (SFC) provides a beneficial substitute for gas chromatography (GC) and liquid chromatography (LC) for certain samples because it merges the top attributes of both techniques. SFC allows the separation and analysis of compounds that GC or LC does not easily manage. These compounds are traditionally nonvolatile or thermally unstable, making GC unsuitable and lacking functional groups required for HPLC analysis.
SFC utilizes a supercritical fluid mobile phase,...
SFC utilizes a supercritical fluid mobile phase,...
248
Gas Chromatography: Types of Detectors-II
371
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
371
Flame Photometry: Lab
246
In a flame photometer, when a solution like potassium chloride is aspirated into the flame, the solvent evaporates, leaving behind dehydrated salt. This salt dissociates into free gaseous atoms in their ground state. Some of these atoms absorb energy from the flame, leading to their excitation. The excited atoms return to the ground state, emitting photons at characteristic wavelengths. Because only electronic transitions are involved, the resulting emission lines are very narrow. The intensity...
246


