中国人群中LDL-R基因多态化与缺血性中风风险之间的关联:元分析
Zhiming Dai1,2, Yifan Wang1, Peidi Li2
1Anesthesia Operation Center, The First People's Hospital of Xianyang, Xianyang, 712099, PR China.
Heliyon
|February 23, 2024
概括
低密度脂蛋白受体 (LDL-R) 基因多态体rs1122608和rs688被分析出缺血性中风风险. 在中国人群中,rs1122608多态性降低了风险,而rs688增加了风险.
科学领域:
- 遗传学 是一个遗传学.
- 神经学 神经学
- 心血管疾病 心血管疾病
背景情况:
- 低密度脂蛋白受体 (LDL-R) 基因多态性与缺血性脑血管疾病有关.
- 之前对LDL-R基因多态性和缺血性中风易感性的研究已经产生了不一致的结果.
研究的目的:
- 进行全面的元分析,评估LDL-R基因多态 (rs1122608和rs688) 与缺血性中风风险之间的关联.
- 澄清特定的LDL-R基因多态性在中国人群中缺血性中风易感性中的作用.
主要方法:
- 在PubMed,Embase,Wanfang Med在线和CNKI数据库中进行了系统的文献搜索.
- 包括七项独立的病例控制研究,涉及来自中国人口的10,355名受试者.
- 使用元分析和聚合分析来计算概率比率 (OR) 和95%置信区间 (CI).
主要成果:
- LDL-R基因的rs1122608多态性与在主导性,异位和等位基因比较模型下降的缺血性中风风险显著相关.
- 在LDL-R基因的rs688多态性显示出与异胞携带者和主导模型下的缺血性中风风险增加的显著关联.
- 所有的分析都是基于中国人口的数据进行的.
结论:
- LDL-R基因rs1122608多态性与缺血性中风风险降低有关.
- 相反,LDL-R基因rs688多态性与中国人口中缺血性中风风险增加有关.
- 建议进行进一步的多中心研究,以验证这些发现及其对缺血性中风易感性的影响.
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