吸烟和BMI调解了教育对腰部疼痛的因果作用:观察性和门德尔随机化分析
Zhangmeng Xu1, Luming Qi1, Huiwu Zhang2
1Department of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Frontiers in endocrinology
|February 23, 2024
概括
高等教育水平显著降低了腰部疼痛 (LBP) 的风险. 针对受教育程度较低的个体的吸烟和体重管理的干预措施可以进一步减轻LBP风险.
科学领域:
- 流行病学 流行病学
- 遗传流行病学遗传流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,教育和腰部疼痛之间存在关联,但因果关系仍然不确定.
- 了解因果关系和潜在的调解因素对于制定有效的预防策略至关重要.
研究的目的:
- 调查教育对腰部疼痛 (LBP) 风险的因果关系.
- 探索生活方式因素,如吸烟和体重指数 (BMI),在教育和LBP之间的关系中扮演的调解角色.
主要方法:
- 采用单变量和多变量门德尔随机化 (MR) 分析来评估教育对LBP的直接和间接影响.
- 利用了来自国家健康和营养检查调查 (NHANES) 数据库 (1999-2004) 的数据,其中包括15580名成年参与者.
- 使用系数乘积或差异方法估计间接影响,并计算调度的比例.
主要成果:
- 每增加4.2年的教育时间都与LBP风险降低48%有关 (OR=0.52).
- 高中以上学历的人与不到高中学历的人相比,LBP风险降低了28% (OR=0.72).
- 在MR分析中,吸烟占教育对LBP总影响的12.8%,BMI占5.9%. 联合调解率为27.6%. 根据NHANES的数据,吸烟影响了34.3%的效果,而BMI则没有.
结论:
- 更高的教育程度会对腰部疼痛 (LBP) 有保护作用.
- 旨在戒烟和控制体重的公共卫生干预措施,特别是对于教育程度较低的人来说,可能有助于减少LBP的发生率.
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