来自肠道微生物群的短链脂肪酸和抑郁症:深入了解生物机制和潜在应用
Junzhe Cheng1,2, Hongkun Hu2, Yumeng Ju1,3
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
General psychiatry
|February 23, 2024
概括
由肠道微生物群产生的短链脂肪酸 (SCFA) 显著影响肠-大脑轴和抑郁. 了解这些微生物代谢物为新型抑郁症治疗提供了潜力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群,被称为"第二大脑",通过微生物群-肠道-大脑轴影响中枢神经系统.
- 肠道微生物群的代谢物,特别是短链脂肪酸 (SCFA),在维持生物体的健康和疾病状态方面发挥着至关重要的作用.
- SCFA与神经精神疾病的病理生理学有关,包括抑郁症.
研究的目的:
- 审查主要SCFA (乙酸盐,酸盐,丁酸盐) 在抑郁症中的作用.
- 探索SCFA参与慢性大脑低 perfusion,神经炎症,表观遗传学和与抑郁症相关的神经内分泌变化.
- 突出微生物向治疗抑郁症的临床潜力.
主要方法:
- 文献审查侧重于SCFA和抑郁症.
- 分析SCFA在主要抑郁病理生理路径中的作用.
- 在抑郁症中对微生物群-肠-大脑轴的当前知识的综合.
主要成果:
- 乙酸盐,酸盐和丁酸盐通过对大脑血液流动,炎症和宿主基因表达的影响影响抑郁症.
- SCFA调节与抑郁症相关的神经内分泌功能.
- 有证据表明,SCFA是抑郁症中微生物群-肠-大脑轴内的复杂相互作用的组成部分.
结论:
- SCFA是关于抑郁症的肠-大脑轴中的关键调解器.
- 了解SCFA机制为开发基于微生物群的抑郁症治疗提供了基础.
- 准肠道微生物群代谢物是抑郁症的有希望的治疗途径.
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