在COVID-19后出现的新发性自身免疫性疾病
Corrilynn O Hileman1,2, Shahdi K Malakooti1,2, Nirav Patil3
1Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Frontiers in immunology
|February 23, 2024
概括
COVID-19 (冠状病毒疾病) 可以引发自身免疫性疾病 (AD),并增加皮肤血管炎等疾病的风险. 然而,在感染Omicron变种后,患AD的风险似乎较低.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 感染可以激活免疫系统,可能导致自身免疫性疾病 (AD).
- 虽然已经报告了COVID-19和新发性AD之间的关联,但与不同SARS-CoV-2菌株相关的具体风险仍然不清楚.
研究的目的:
- 调查COVID-19诊断后各种自身免疫性疾病的发生率和风险.
- 为了比较感染不同SARS-CoV-2变种后AD的风险.
主要方法:
- 使用TriNetX研究网络分析了一大批被诊断为COVID-19的成年患者 (2020年1月至2023年3月).
- 没有COVID-19的年龄和性别倾向得分匹配的对照被用于比较.
- 排除了先前或感染后立即患有AD的患者;结果评估是在指数日期后1个月至1年.
主要成果:
- 在COVID-19后观察到某些AD的风险更高,包括皮肤血管炎,多关节炎和过敏性血管炎.
- 牛皮,类风湿性关节炎和1型糖尿病的发病率最高,牛皮和糖尿病在COVID-19后的可能性增加.
- 当COVID-19在Omicron变种占主导地位期间被诊断出来时,患AD的风险较低. 阳性抗核抗体预测了COVID-19后的AD.
结论:
- SARS-CoV-2 可能会成为某些自身免疫性疾病的触发因素.
- 在COVID-19感染后患AD的风险可能会通过像Omicron.com这样的新型变种降低.
相关概念视频
Autoimmune Disorders
436
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
436
Immunodeficiency Diseases
939
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
939
Immunological Memory
613
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
613
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Gastritis-II: Pathophysiology
326
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
326
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K


