针对MYC,在癌症代谢和瘤免疫学之间的交叉点
Simran Venkatraman1, Brinda Balasubramanian2, Chanitra Thuwajit3
1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Frontiers in immunology
|February 23, 2024
概括
通过改变新陈代谢和免疫力,MYC激活驱动癌症. 这篇评论探讨了MYC的情况.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- MYC激活是癌症进展的关键驱动因素.
- MYC影响癌症新陈代谢 (上代谢) 和免疫反应 (上免疫学).
- 理解MYC网络对于开发有效的癌症疗法至关重要.
研究的目的:
- 审查MYC在代谢和免疫学中的作用.
- 阐明MYC如何调节癌症中的基因转录和细胞代谢.
- 讨论针对MYC驱动癌症的治疗策略.
主要方法:
- 对MYC在癌症中的功能现有知识的文献综述.
- 探索MYC网络特征的多Omic方法.
- 分析MYC与HIF-1α等关键因素的相互作用.
主要成果:
- MYC显著影响葡萄糖和谷氨酸的新陈代谢.
- MYC影响调节性T细胞中的抗原呈现和代谢重编程.
- 特定的MYC基因标参与癌症中的代谢和免疫功能.
结论:
- MYC通过代谢和免疫调节在塑造瘤微环境方面发挥着关键作用.
- 准MYC为各种癌症提供了一个有希望的治疗途径.
- 对MYC网络的进一步研究可以揭示新的治疗策略.
更多相关视频
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Induced Pluripotent Stem Cells
4.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.1K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


