在疑似冠状动脉疾病的患者中,周冠状动脉炎症和冠状动脉功能之间的关系
Mengyu Chen1,2,3, Bing Liu1,2,3, Xu Li1,2,3
1Department of Radiology, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China.
周冠状动脉脂肪组织的脂肪减弱指数 (FAI) 与疑似冠状动脉疾病 (CAD) 患者的冠状动脉流量储备 (CFR) 的减少有关. 即使没有阻塞性心上动脉狭窄,FAI也可以识别微循环损伤.
科学领域:
- 心血管成像 - 心血管成像
- 放射学 放射学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 冠状动脉疾病 (CAD) 诊断依赖于评估冠状动脉功能.
- 周冠状动脉脂肪组织 (PCAT) 的特征可能反映了潜在的炎症和血管功能障碍.
- 脂肪减弱指数 (FAI) 是PCAT属性的新型CT衍生标记.
研究的目的:
- 在怀疑CAD的患者中,研究PCAT衰减 (FAI) 和冠状动脉流量储备 (CFR) 之间的关联.
- 为了确定FAI是否可以预测冠状动脉微血管功能受损.
- 评估FAI在患有或没有阻塞性CAD的患者中的实用性.
主要方法:
- 364名怀疑患有CAD的患者接受了PET/CT和冠状动脉计算机断层扫描血管学 (CCTA).
- 冠状动脉流量储备 (CFR) 用PET/CT进行评估.
- 量化了PCAT和冠状动脉的脂肪减弱指数 (FAI) 和其他CT衍生的参数.
主要成果:
- 在57%的患者中观察到降低CFR (<2.5).
- 降低CFR患者的FAI值更高,扩散性动脉样硬化患病率更高.
- 在血管层面的分析中,降低CFR与阻塞性CAD,扩散性动脉样硬化,低衰减斑块和积极重塑有关.
- FAI与CFR独立相关,即使在对传统风险因素进行调整后,在没有阻塞性CAD的患者中也是如此.
结论:
- 由FAI评估的冠状动脉周围血管炎症与冠状动脉血管功能独立相关.
- 在CFR降低的患者中,FAI升高,特别是在没有阻塞性冠状动脉疾病的患者中.
- FAI作为一种有价值的成像生物标志物,用于检测疑似CAD的微循环功能障碍.
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