轮班工作与白细胞数量增加有关:系统性审查和元分析
Piumika Sooriyaarachchi1,2, Ranil Jayawardena1,3, Toby Pavey1
1Queensland University of Technology (QUT), Faculty of Health, School of Exercise and Nutrition Sciences, Brisbane, Queensland, Australia.
Indian journal of occupational and environmental medicine
|February 23, 2024
概括
轮班工作与较高的白细胞 (WBC) 数量有关,包括淋巴细胞和单细胞. 这些白细胞计数可以作为轮班工人疾病风险的生物标志物.
科学领域:
- 职业健康 职业健康 职业健康
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 轮班工作与慢性炎症和疾病进展有关.
- 白细胞计数是感染和疾病的指标.
- 了解轮班工人的WBC变化对于健康监测至关重要.
研究的目的:
- 系统地审查和对轮班员工的WBC总和差异计数的证据进行元分析.
- 为了比较轮班工人和日职工之间的WBC资料.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行了全面的文献搜索.
- 使用随机效应模型对25项研究的数据进行了元分析.
- 包括的研究包括来自不同地理区域的37,708名参与者.
主要成果:
- 轮班工作人员的白细胞总计数显著增加 (MD = 0.43;P < 0.001).
- 在轮班工人中观察到高水平的淋巴细胞 (MD = 0.16; P = 0.02),单细胞 (MD = 0.04; P = 0.03) 和乙素 (MD = 0.01; P = 0.03).
- 在中性粒细胞或基基粒细胞计数方面没有发现显著差异.
结论:
- 轮班工作导致总和差异性WBC数量的显著增加.
- 白细胞计数可以作为可访问的生物标志物,用于轮班工人疾病诊断和预后.
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