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纳夫托金衍生物作为潜在的免疫调节剂:对COVID-19治疗的前景

Vitor Tassara Moraes¹, Franco Jazon Caires¹, Pedro V da Silva-Neto²

¹Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo-USP Ribeirão Preto 14040-903 SP Brazil gclososki@usp.br +55 16 3315-4208.

|February 23, 2024

概括

这项研究探讨了一种真菌纳夫托金,3,5,8-TMON及其衍生物的抗炎和抗病毒作用. 这些化合物显示出降低炎症标志物和抑制细胞培养中的SARS-CoV-2感染的潜力.

科学领域:

自然产品化学化学
免疫学免疫学免疫学
病毒学病毒学

背景情况:

失调的炎症是严重的COVID-19结果的关键因素.
纳夫托基诺,如真菌中的3,5,8-TMON,显示出潜在的生物益处.
关于3,5,8-TMON的特性,特别是其抗炎和抗病毒作用的研究有限.

研究的目的:

评估3,5,8-TMON及其合成衍生物的抗炎和抗病毒作用.
研究它们对脂聚糖 (LPS) 诱导的炎症和SARS-CoV-2感染的影响.
探索对NF-kB,NO,IL-6和TNF等炎症标志物的度依赖性影响.

主要方法:

提取和酸性处理的真菌原始提取物 (科尔迪塞普斯种) 的提取. 为了获得3,5,8-TMON.
通过与氨酸反应合成两种新型衍生物 (3和4).
在体外细胞培养实验中,使用RAW 264.7,THP-1和Calu-3细胞进行了LPS或SARS-CoV-2的挑战.

主要成果:

原料提取物抑制了RAW 264.7细胞中LPS诱导的NF-kB,氧化 (NO) 和IL-6的产生.
3,5,8-TMON和衍生物3和4调节了THP-1细胞中的IL-6和TNF产生,以度依赖的方式.
在SARS-CoV-2感染期间,3,5,8-TMON显著降低了Calu-3细胞中的IL-6产生.

结论:

3,5,8-TMON及其衍生物具有有前途的抗炎和抗病毒特性.
这些化合物显示出治疗炎症和病毒感染的潜力,包括COVID-19.
进一步研究纳夫托基诺作为治疗剂是有必要的.

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