外围乙酸细胞数量与慢性病之间的关联:来自NHANES 1999-2018年的证据
Shisheng Han1, Meng Jia1, Wenli Yuan1
1Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Renal failure
|February 23, 2024
概括
周围乙酸细胞计数 (PEC) 与慢性病 (CKD) 有关. 在CKD患者中,较高的PEC (低于400细胞/uL) 与较低的eGFR和较高的UACR相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 周围乙酸细胞数量 (PEC) 与功能障碍有关.
- 慢性病 (CKD) 的患病率需要了解其相关的生物标志物.
- 本研究使用国家调查数据调查PEC-CKD关系.
研究的目的:
- 探索外围乙酸细胞计数 (PEC) 和慢性病 (CKD) 之间的关联.
- 为了确定PEC与CKD关键指标的相关性:估计的淋巴膜过率 (eGFR) 和尿与肌素的比率 (UACR).
主要方法:
- 对NHANES数据 (1999-2018) 的横截面分析,涉及9224名非透析CKD参与者.
- 使用了调查加权的通用多变量线性回归模型.
- 限制的立方线线评估了非线性关联,敏感性分析确保了结果的稳定性.
主要成果:
- 在PEC和eGFR之间发现了负相关性 (β = -0.71每100个细胞/uL增加).
- 在PEC和UACR之间观察到一个积极的趋势 (β = 10.21/100细胞/uL增加).
- 这些关联在0-400细胞/uL的PEC范围内是显著的.
结论:
- 在CKD患者中,PEC<400细胞/uL的循环中氨基酸水平与eGFR相反相关,与UACR呈正趋势.
- 研究结果表明,PEC可能作为CKD的潜在生物标志物.
- 建议进行进一步的研究以验证这些关联.
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