氧化应激,微粒和E-selectin并不依赖于HIV抑制
概括
艾滋病毒感染者表现出更高的氧化应激和炎症标志物,无论治疗方式如何. 这些因素有助于过早的免疫衰老和与年龄相关的疾病,即使控制病毒载量.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 氧化应激和炎症与衰老和与年龄相关的疾病有关.
- 在艾滋病毒 (人类免疫缺陷病毒) 感染者身上研究这些标志物旨在了解过早免疫发育.
- 这项研究探讨了艾滋病毒感染者对早期发病的年龄相关疾病的潜在倾向.
研究的目的:
- 在接受抗逆转录病毒治疗的HIV患者中评估氧化应激,炎症和内皮激活标志物.
- 为了确定这些标志物是否表明HIV阳性个体的免疫性表型.
- 探索这些标志物与与年龄有关的疾病发展之间的关系.
主要方法:
- 研究包括213名艾滋病毒感染者和艾滋病毒阴性对照.
- 通过马隆迪化物 (MDA) 测量氧化应激,使用硫甲酸反应物质 (TBARS) 试验.
- 使用微粒和E-选择素水平评估炎症和内皮激活.
主要成果:
- 与对照组相比,在艾滋病毒感染者中观察到显著更高的TBARS,微粒子和E-选择素水平 (P<0.001).
- 在接受治疗和未接受治疗的HIV组之间,没有发现这些标志物水平的显著差异.
- 这些标记物与CD4+计数,CD4+/CD8+比率或HIV-1RNA水平之间没有发现显著的相关性.
结论:
- 艾滋病毒感染者的高氧化应激,炎症和内皮激活标志物独立于病毒学和免疫学状态.
- 这些发现支持了细胞储库中的残留病毒病在过早免疫衰老中的作用.
- 这表明,艾滋病毒感染者有倾向于早期发病的与年龄有关的疾病.
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