与慢性病相关的代谢功能障碍的严重程度和缓解 脂肪/脂肪性肝病与慢性病的发生
Jingli Gao1, Yuhao Li2,3, Yijun Zhang4,5,6
1Department of Intensive Care Unit Kailuan General Hospital Tangshan China.
Journal of the American Heart Association
|February 23, 2024
概括
慢性病 (CKD) 的风险随着代谢功能障碍相关的脂肪肝疾病 (MAFLD/MASLD) 的严重程度而增加. 即使在MAFLD/MASLD缓解后,中度至重度病例仍然存在更高的CKD风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD/MASLD) 是一个日益严重的健康问题.
- 在MAFLD/MASLD严重程度,缓解和慢性病 (CKD) 风险之间的关系尚未完全理解.
研究的目的:
- 调查MAFLD/MASLD严重程度和缓解与CKD发病率之间的关联.
- 为了澄清肝脏肥胖症等级对MAFLD/MASLD患者中CKD风险的影响.
主要方法:
- 采用了Kailuan队列 (79540名参与者) 的数据,随访时间中位数为12.9年.
- MAFLD/MASLD通过超声波诊断,并通过代谢功能障碍定义,不包括其他肝病原因.
- 根据估计的淋巴膜过率<60mL/min/1.73m2或蛋白尿 (≥1+) 定义的CKD. 使用了考克斯回归模型.
主要成果:
- MAFLD/MASLD与CKD风险增加有关 (HR 1.12),随着肝硬化症严重程度的增加,这种风险升级 (P趋势<0.001).
- 与持续的非MAFLD相比,MAFLD缓解并没有显著改变CKD风险.
- 特别是在中度/重度肥胖症中,MASLD的缓解仍然与更高的CKD风险有关.
结论:
- 在MAFLD/MASLD患者中,CKD风险与肝硬化症的严重程度直接相关.
- 在MAFLD/MASLD中,先前的中度至重度肝肥胖症,即使在疾病缓解后,也会持续增加CKD风险.
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