Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

697
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
697
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

5.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.9K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

7.6K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.6K
Coagulation01:09

Coagulation

6.6K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.6K
Introduction to Hemostasis01:05

Introduction to Hemostasis

7.7K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.7K
Disorders of Hemostasis01:24

Disorders of Hemostasis

906
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
906

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Patient blood management in general intensive care patients.

Intensive care medicine·2026
Same author

Defining a fibrinogen-to-factor XIII replacement ratio in an in-vitro model of dilutional coagulopathy.

Thrombosis research·2026
Same author

Impact of Systemic Vessel Resistance and Microaxial Pump Flow Level on Left Ventricular Workload.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Long-distance trail running induces functional iron deficiency driven by inflammation.

Blood advances·2026
Same author

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients.

Scientific reports·2026
Same author

Differences in the Phenotype of Bacterial and Viral Sepsis-A Prospective, Multicenter, Observational Study.

Viruses·2025

相关实验视频

Updated: Jul 2, 2025

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

21.9K

在创伤后进行血栓形成预防.

Johannes Bösch1, Mirjam Bachler2, Dietmar Fries1

  • 1Department for Anaesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Current opinion in anaesthesiology
|February 23, 2024
PubMed
概括

标准的低分子量肝素 (LMWH) 剂量往往不足以预防创伤患者的静脉血栓栓塞事件 (VTE). 使用抗Xa监测或替代抗凝剂进行个性化预防,对于有效降低VTE风险至关重要.

更多相关视频

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

858
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

755

相关实验视频

Last Updated: Jul 2, 2025

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

21.9K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

858
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

755

科学领域:

  • 创伤和紧急医疗医学
  • 药理学和治疗学 药理学和治疗学
  • 血液学 血液学 血液学

背景情况:

  • 严重创伤患者经常经历静脉血栓栓塞事件 (VTE),尽管标准的血栓塞预防.
  • 目前的指导方针通常依赖于低分子量肝素 (LMWH) 或未分离肝素 (UFH),这可能是不充分的.

研究的目的:

  • 审查在重大创伤中对VTE标准药理学预防的局限性.
  • 探索目前在创伤指南中未涉及的,用于预防血栓形成的替代策略.

主要方法:

  • 对创伤患者VTE预防的最新研究的综述.
  • 影响皮下LMWH疗效的因素分析.
  • 对替代抗凝方法的评估.

主要成果:

  • 根据抗Xa水平监测和调整皮下LMWH剂量,可以减少创伤患者的静脉瘤.
  • 诸如器官功能,抗素水平和药物相互作用等可变因素需要剂量调整.
  • 静脉输入的LMWH,UFH和gaaratroban在重症监护机构中表现有前途.

结论:

  • 标准的皮下LMWH剂量往往不足以有效预防创伤中的VTE.
  • 需要个性化的方法,包括抗Xa水平监测或替代性抗凝药,以减轻VTE风险.
  • 优化预防可以减少不充分预防和随后的VTE的发生率.