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在神经性厌食症中肠道微生物组的变化:综合性审查
Wendi Zhao1, Prabhath Kodancha2, Soumitra Das2
1Department of Psychiatry, University of Melbourne, Parkville, Melbourne 3052, Australia.
概括
肠道微生物群的不平衡与神经性厌食症 (AN) 有关. 在AN患者中观察到有益细菌减少和甲产生细菌增加,可能会恶化炎症和半星化.
科学领域:
- 微生物组研究的研究.
- 精神疾病 精神疾病
- 人类肠道微生物组
背景情况:
- 神经性厌食症 (AN) 在精神病管理中提出了重大挑战,其潜在的病理生理学仍然不清楚.
- 新出现的证据表明,肠道微生物群失生症在AN的发展和进展中可能发挥作用.
研究的目的:
- 研究人类肠道微生物群与神经性厌食症之间的联系.
- 为了探索肠道微生物组成和AN患者的再综合征之间的关系 (目标2在审查的研究中没有解决).
主要方法:
- 通过使用MEDLINE和PsycINFO数据库进行了对研究的系统审查.
- 包括的研究集中在精神性厌食症患者的肠道微生物群.
- 分析了14项涉及476名AN患者和554名健康对照者的研究数据.
主要成果:
- 与健康对照组相比,患有AN的患者表现出明显较低的*Faecalibacterium prausnitzii*和*Roseburia inulinivorans*水平.
- 在AN患者中,持续观察到 *Methanobrevibacter smithii* 的丰富性增加.
- 虽然α多样性变化不一致,但β多样性分析表明AN中的微生物社区结构发生了变化.
结论:
- 肠道微生物群失调,以特定的细菌转移为特征,可能会导致神经性厌食症的病理生理学.
- 减少微生物短链脂肪酸的产生,与失生症相关,可能会促进AN的炎症状态.
- 微生物的变化可能会影响能量利用和内分泌的变化,加剧AN的半星化.
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