儿童便微生物群移植:系统性审查
Ella Lauwers1, João Sabino2,3, Ilse Hoffman1
1Department of Paediatric Gastroenterology & Hepatology & Nutrition, University Hospitals Leuven, Leuven, Belgium.
Acta paediatrica (Oslo, Norway : 1992)
|February 23, 2024
概括
便微生物群移植 (FMT) 对复发性Clostridioides difficile感染是有效的,但对其他疾病缺乏足够的证据. 需要更多的儿科研究来评估FMT在各种疾病中的安全性和有效性.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在人类健康和疾病中起着至关重要的作用.
- 肠道微生物不平衡的失生症与各种胃肠道疾病有关.
- 便微生物种移植 (FMT) 是一种新兴的疗法,用于恢复肠道微生物平衡.
研究的目的:
- 系统地审查有关FMT在各种适应症中的有效性和安全性的现有证据.
- 评估FMT在复发性Clostridioides difficile感染之外的作用.
- 发现研究中的差距,并指导未来的研究.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 截至2022年10月,从Embase和PubMed提取了583篇文章.
- 在最终分析中包括了50项研究,根据FMT的指示,设计,有效性和安全性进行分类.
主要成果:
- 在复发的Clostridioides difficile感染中,FMT是安全有效的.
- 在儿科病例中报告了严重的不良事件.
- 目前没有足够的数据支持FMT治疗易发性肠道疾病,炎症性肠道疾病或肥胖.
- FMT可能有助于去殖民多药耐药生物.
结论:
- 对儿童进行进一步的随机,受控,前性队列研究是必不可少的.
- 研究的重点应该是评估在不同儿科条件下FMT的有效性.
- 解决出版偏见对于准确的治疗评估至关重要.
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