在食道切除术后的胆胸部治疗中,奥克特雷奥提德的作用
Nathaniel Deboever1, Hope Feldman1, Michael Eisenberg1
1Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
概括
在食道切除术后,奥克特雷奥提德并没有显著改善成年患者的结局,这些患者经历了性泄漏. 这项研究发现,使用奥克胺与胸腔管持续时间的缩短,住院时间或生存率的改善之间没有关联.
科学领域:
- 胸部外科手术 胸部外科手术
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 胸内胆漏是食道切除术后的一种并发症.
- 奥克特雷奥提德越来越多地用于质泄漏,在儿科患者中具有既定的益处.
- 在成年人食道切除术后的胆泄漏中,奥克提德疗效的证据有限.
研究的目的:
- 为了评估奥克特雷奥提德在治疗胸内性漏术后的成年患者中的疗效.
- 评估奥克胺对胸腔管持续时间,住院时间和整体存活率的影响.
主要方法:
- 单一机构前性队列研究.
- 从专门的数据库中分析临床病理学特征.
- 使用了卡普兰-梅尔和多变量考克斯回归分析.
主要成果:
- 74名患者符合纳入标准;27名患者 (36.5%) 接受了奥克.
- 奥克特雷奥提德对胸管持续时间没有显著影响 (P=0.890).
- 没有观察到对住院时间 (P=0.740) 或整体存活率 (P=0.570) 的显著影响.
结论:
- 在患有食道切除术后质泄漏的成年患者中使用奥克特雷奥提德与改善的临床结果无关.
- 需要进一步的高水平证据 (一级) 才能考虑为这个患者群体考虑octreotide.
- 目前的证据不支持为此指标常规使用八二.
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