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High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
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在单分子水平上探测囊泡重建β2上腺素受体的激活和形态动力学

Marijonas Tutkus1,2,3, Christian V Lundgaard1, Salome Veshaguri1

  • 1Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.

The journal of physical chemistry. B
|February 23, 2024
PubMed
概括

单个G蛋白结合受体 (GPCR),如β2上腺素受体 (β2AR),表现出动态的结构变化. 激素结合改变了这些动态,影响了与原生相似的膜环境中的受体信号表型.

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