聚乙烯甘醇与乳糖相比治疗怀孕期间便秘:一项随机对照试验
Victoria Ivy Raj1, Azyyati Hassan1, Nurulashikin Hanafiah1
1Department of Obstetrics and Gynecology, Faculty of Medicine, University Malaya, Jalan Profesor Diraja Ungku Aziz, Kuala Lumpur, Malaysia.
聚乙烯甘4000 (PEG) 和乳糖是有效的治疗妊娠期间的慢性便秘. PEG显示出更好的症状改善和更少的腹等副作用的趋势.
科学领域:
- 产科和妇科 产科和妇科
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性便秘是影响孕妇的常见疾病.
- 药经常用于管理怀孕期间的便秘.
研究的目的:
- 为了比较聚乙烯甘醇4000 (PEG) 与乳糖在治疗孕妇慢性便秘方面的疗效和安全性.
主要方法:
- 一项随机对照试验涉及247名被诊断患有慢性便秘的孕妇 (妊娠28-32周).
- 参与者接受PEG 4000 (10克/天) 或乳糖 (10克/天) 治疗4周.
- 结果包括完整的自发性肠道排便 (CSBM),患者对便秘症状的评估 (PAC-SYM) 评分,生活质量 (PAC-QoL) 和便的一致性 (布里斯托尔便形式尺度).
主要成果:
- PEG和乳糖都在怀孕期间控制便秘方面表现出有效性.
- 与乳糖相比,PEG显示了PAC-SYM得分的统计学上显著改善 (52.5%与37.3%相比).
- 与乳糖相比,PEG与腹和便的发病率较低有关.
结论:
- 聚乙烯甘醇4000和乳糖都是有效的药,用于治疗怀孕期间的慢性便秘.
- 与乳糖相比,PEG 4000可能具有有利的副作用概况,特别是在腹和松散便方面.
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