脊髓损伤的抗生素预防与泌尿动力学研究:评估实践模式和结果,以指导未来在单一中心的实践
Du Pham1, Bradley Chi1, Felicia Skelton1,2,3
1H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
The journal of spinal cord medicine
|February 23, 2024
概括
尿路感染 (UTI) 在脊髓损伤 (SCI) 患者中很常见. 一项研究发现,在 gentamicin 预防中没有发现尿动力学后尿路感染,这表明在 SCI 护理中改善抗生素管理的潜力.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 脊髓损伤医学 脊髓损伤医学
背景情况:
- 尿路感染 (UTI) 是脊髓损伤 (SCI) 患者的常见并发症.
- 在接受尿动力学研究 (UDS) 的SCI患者的抗生素预防方面缺乏共识.
- 这项研究解决了在这种患者群体中需要基于证据的指导方针的需求.
研究的目的:
- 评估SCI患者接受UDS的局部抗生素预防模式.
- 评估术后尿道感染的发生率.
- 描述当地的抗生素耐药性趋势,并告知抗生素管理.
主要方法:
- 退伍军人事务SCI中心331名SCI患者的回顾性队列研究 (2010-2020).
- 数据提取包括人口统计,尿路感染风险因素,手术前尿液分析/培养和手术前抗生素.
- 用描述性统计数据来总结发现.
主要成果:
- 在49%的病例中,手术前的尿液培养结果呈阳性,其中大肠杆菌是最常见的生物体 (19%).
- 86%的病例中使用了抗生素,最常见的是单剂量肌内 gentamicin (53%).
- 在研究期间没有发现任何手术后的尿路感染.
结论:
- 当前的当地实践,包括胺预防,在SCI患者中与零后UDS尿路感染有关.
- 低的尿路感染发病率表明,目前的预防可能需要改进,以便更好地管理抗生素.
- 对接受UDS的SCI患者的最佳抗生素策略进行进一步的研究是有必要的.
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