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来自Pseudeurotium bakeri的林根和[11]-甲基球蛋白及其免疫抑制活性

Fangfang Duan^1,2, Chunlun Qin¹, Zihuan Sang²

¹School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. ruanhl@hust.edu.cn.

Organic & biomolecular chemistry

|February 23, 2024

概括

研究人员从真菌Pseudeurotium bakeri中发现了新的化合物. 一些化合物表现出抗癌和免疫抑制活性,包括T细胞亡诱导.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.

背景情况:

内生菌是新生物活性代谢物的丰富来源.
木 (Pseudeurotium bakeri) 是一种内性真菌,有可能产生独特的化学结构.

研究的目的:

从Pseudeurotium bakeri中分离和描述新的化合物.
评估分离化合物的细胞毒性和免疫抑制活性.

主要方法:

使用光谱数据 (NMR,MS) 和X射线衍射的结构阐明.
通过电子圆二元论 (ECD) 和修改的莫舍尔法来确定绝对配置.
在体外检测细胞毒性和免疫抑制活性 (T和B细胞增殖).

主要成果:

确定了两种新型的原体和四种新型的[11]-甲基球蛋白.
化合物5和6对人类癌症细胞系表现出中度细胞毒性.
化合物2-4对T和B细胞增殖表现出显著的免疫抑制作用.
化合物2和3在激活的T细胞中诱导了亡.

结论:

伪黄 (Pseudeurotium bakeri) 在结构上产生了新联和链球蛋白.
隔离的化合物具有作为抗癌和免疫抑制剂的潜力.
对这些化合物的进一步研究可能会导致新的治疗方法.

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