血管适应运动:对女性代表性的系统审查和审计
Sarah L Thompson1, Carly J Brade1, Sarah R Henley-Martin1
1Exercise Science, Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.
American journal of physiology. Heart and circulatory physiology
|February 23, 2024
概括
关于运动和血管适应的研究表明,男性有显著的偏见. 研究往往缺乏对女性参与者的方法严格性,特别是在月经周期跟踪方面,阻碍了质量证据的产生.
科学领域:
- 生理学 生理学 生理学
- 运动科学 运动科学
- 血管生物学 血管生物学
背景情况:
- 生物性别影响运动诱导的血管适应.
- 现有的研究显示出了显著的男性偏见.
- 女性研究的方法质量在很大程度上是未知的.
研究的目的:
- 系统地审查和综合有关健康个体和运动员运动干预和内皮功能的证据.
- 评估涉及女性参与运动诱导血管适应研究的研究的方法质量.
- 量化女性的代表性,并确定在生理学研究中遵守最佳实践.
主要方法:
- 210项研究 (5,997名参与者) 的系统综述和叙事综合.
- 应用标准化审计框架来评估女性参与者的代表性.
- 使用分层分级系统来确定符合女性生理学研究最佳实践建议的研究.
主要成果:
- 女性占研究总人数的39%,但运动员的比例为49%.
- 只有5%的研究符合最佳实践指南,主要是在更年期和孕妇队列中.
- 没有对自然月经,荷尔蒙避孕药使用者或月经不规则者进行的研究符合所有建议.
结论:
- 在运动诱导的血管适应研究中,女性的代表性显著不足,并且缺乏高质量的证据.
- 缺乏对卵巢激素的方法控制,特别是整个月经周期,是一个关键的差距.
- 优先考虑月经状况报告对于改善女性血管和运动研究证据质量至关重要.
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