在患有血液性恶性病的患者中,阿斯伯吉洛症的危险因素和环境预防措施
Daniel Raposo Puglia1, José Ángel Raposo Puglia2, Emilio García-Cabrera3
1Department of General and Digestive Surgery, Hospital Universitario Jerez de la Frontera, Ronda de Circunvalación s/n, 11407 Jerez de la Frontera, Spain.
环境控制措施是预防血液恶性瘤患者侵入性阿斯伯吉洛症 (IA) 的关键. 抗真菌预防不如环境控制有效,应该是互补的.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 医院流行病学 医院流行病学
背景情况:
- 侵入性阿斯伯吉洛症 (IA) 是一种严重的真菌感染,在血液恶性瘤患者中很常见.
- 与IA相关的高死亡率和发病率需要有效的预防策略.
- 风险分层对于量身定制预防措施以满足个体患者需求至关重要.
研究的目的:
- 为了识别入侵性阿斯伯吉洛症的近期风险因素.
- 评估环境控制措施,以减少医院IA的发生率.
- 建立基于证据的针对IA的预防行动.
主要方法:
- 科学文献的定性系统审查.
- 在Medline,Cochrane和Scopus数据库中进行了搜索.
- 遵循PRISMA和STROBE的数据收集和分析指南.
主要成果:
- 环境控制措施是减少IA发生率的最有效干预措施.
- 独立的危险因素包括中性质衰竭,真菌污染,环境控制不足,长时间住院和贫血.
- HEPA,LAF和Plasmair®系统有效地减少空气中的真菌子.
- 抗真菌预防没有显著影响IA减少.
结论:
- 医院的专业培训和强有力的环境控制对于IA预防至关重要.
- 建议优化血液恶性瘤患者的风险分层.
- 抗真菌预防应该补充,而不是取代环境控制措施.
- 需要进一步的研究来评估家庭环境控制对IA的有效性.
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