交叉链接的 hialuronan 衍生物在提供 phycocyanin 的过程中
Francesca Terracina1, Mario Saletti2, Marco Paolino2
1Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Gels (Basel, Switzerland)
|February 23, 2024
概括
研究人员开发了使用点击化学用于药物输送的新型交联氨酸 (HA) 水凝. 这些以HA为基础的材料有效地加载和保护抗氧化剂植物 (PC),使得可控,pH值依赖的释放具有保存活性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 氨酸 (HA) 是一种生物相容的聚合物,具有药物输送潜力.
- 交叉连接HA可以为控制释放应用程序创建稳定的水凝结构.
- 点击化学为聚合物修饰和交联提供了一种高效的方法.
研究的目的:
- 使用点击化学开发新的交联HA基材料.
- 为了研究这些材料中的 phycocyanin (PC) 的加载和释放特性.
- 评估这些材料作为pH依赖药物递送系统 (DDS) 的潜力.
主要方法:
- 在HA和咖啡酸衍生物上用propargyl组对ferulic acid (FA) 和具有azido终结的oligo ((乙烯基醇)) 侧链的咖啡酸衍生物进行移植.
- 使用铜 ((I) 催化化 1,3-双极循环添加 (点击交叉连接) 来形成水凝.
- 材料结构的表征,聚合,和荷载的 phycocyanin (PC);体外溶解研究和DPPH测定抗氧化活性.
主要成果:
- 成功合成交联HA-移植-FA共聚合物,并将其与PC复合.
- 两种新型复合物,HA(270) -FA-TEGEC-CL-20/PC和HA(270) -FA-HEGEC-CL-20/PC,在药物与物质的比率为1:2的情况下形成.
- 材料证明了PC在体外释放的pH依赖性,受控/延长释放的配置文件,并保留了PC的抗氧化活性.
结论:
- 点击交叉链接是一种可行的方法,用于创建用于药物输送的基于HA的水凝.
- 新的HA-PC复合体显示出作为可调节释放动力学的有效药物递送系统的承诺.
- 开发的DDS保持了充满抗氧化剂的治疗疗效.
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