相关实验视频

Updated: Aug 10, 2026

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

生物活性聚氨-聚乙烯 (乙烯基醇) 二烯酸盐水凝用于组织工程中的应用

Yixuan Yuan¹, Caleb Tyson², Annika Szyniec¹

¹Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.

Gels (Basel, Switzerland)

|February 23, 2024

概括

研究人员开发了可调节的,生物活性聚氨 (PU) 与PEGDA水凝混合. 这些合成的细胞外基质支持细胞粘附和活力,推进组织工程支架.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
聚合物化学聚合物化学

背景情况:

聚氨 (PU) 是多功能生物材料,对生物医学用途进行了广泛的研究.
控制PU材料特性和细胞反应的挑战阻碍了基于PU的组织支架的临床转化.
现有的PU支架往往缺乏可调节的生物功能和机械性能.

研究的目的:

开发一种简单的方法来合成可调节的,生物活性聚氨 (PUs) 与聚乙烯基醇 (PEGDA) 双烯酸盐 (PEGDA) 水凝混合.
创建一个多功能平台,用或蛋白质修改水凝,以赋予特定的生物功能.
为了研究这些新的PU-PEG混合水凝的机械可调性和细胞反应.

主要方法:

合成可光固化的PU和PEGDA水凝.
用PEGylated或蛋白质修改水凝.
通过调整PU和PEGDA比率来调整机械性能.
使用人类细胞进行体外研究,以评估细胞粘附和活力.

主要成果:

成功合成了可调节的,生物活性的PU-PEG混合水凝.
证明了可以通过不同的PU和PEGDA比率来控制机械性能.
已证实,当与细胞粘附质功能化时,水凝支持人体细胞粘附和活力.
展示了通过/蛋白质修饰传递可变生物功能的能力.

结论:

混合PU-PEG水凝提供了一个高度可定制的系统,用于创建合成细胞外基质.
这些材料克服了以往在平衡材料特性与基于PU的支架的细胞反应方面的局限性.
开发的水凝对于需要可适应生物材料的组织工程应用来说是一个有前途的进步.

关键词:

细胞粘附细胞粘附这种水凝是水凝.照片交叉连接照片交叉连接聚乙烯甘醇) 乙烯酸二烯酸盐聚氨是一种聚氨.脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架.组织工程是组织工程.

更多相关视频

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

相关概念视频

Anionic Chain-Growth Polymerization: Overview

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

Types of Step-Growth Polymers: Polyesters

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...

Ion Exchange

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...

Preplaced Aggregate Concrete

Preplaced Aggregate Concrete

Preplaced aggregate concrete is ideal for construction environments that are not easily accessible. The process begins by properly wetting the gap-graded coarse aggregates to remove the dirt, then placing it in the form and compacting it. Voids are filled with a mortar mix pumped under pressure through slotted pipes. This mortar typically consists of Portland cement, pozzolan, fine aggregates, water, and a fluidizing aid. The pozzolan helps reduce bleeding and segregation while improving the...

Plasticizers

Plasticizers

Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...

Superplasticizers

Superplasticizers

Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...